In October, the weather in Puerto Maldonado is typically hot. Average daily high temperature in October is about 31 degrees above zero. On average, Puerto Maldonado has 21 rainy, 5 partly cloudy, 3 sunny, and 2 cloudy days in October. The rains are usually heavy. October as well as January, February, March, and April is considered the most uncomfortable time to visit Puerto Maldonado.