April in La Crosse is the rainiest month of the year. In April, the weather in La Crosse is typically warm. Average daily high temperature in April is about 11 degrees above zero. On average, La Crosse has 13 rainy, 9 cloudy, 6 sunny, and 2 partly cloudy days in April. The rains are usually heavy. April as well as January, March, and November is considered the most uncomfortable time to visit La Crosse.