October in Cayo Largo is the rainiest month of the year. In October, the weather in Cayo Largo is typically hot. Average daily high temperature in October is about 28 degrees above zero. On average, Cayo Largo has 14 rainy, 10 sunny, 5 partly cloudy, and 2 cloudy days in October. The rains are usually moderate. October as well as June, August, and September is considered the most uncomfortable time to visit Cayo Largo.