February in Cayo Largo is the coldest month of the year. In February, the weather in Cayo Largo is typically warm. Average daily high temperature in February is about 25 degrees above zero. On average, Cayo Largo has 27 sunny, 1 rainy, and 1 partly cloudy day in February. The rains are usually light. February as well as January, March, April, and December is considered the most comfortable time to visit Cayo Largo.