In September, the weather in Agios Nikolaos is typically hot. Average daily high temperature in September is about 28 degrees above zero. On average, Agios Nikolaos has 25 sunny, 3 rainy, and 2 partly cloudy days in September. The rains are usually light. September as well as April, May, June, and August is considered the most comfortable time to visit Agios Nikolaos.