March in Cayo Santa Maria is the windiest month of the year. In March, the weather in Cayo Santa Maria is typically warm. Average daily high temperature in March is about 25 degrees above zero. On average, Cayo Santa Maria has 22 sunny, 7 partly cloudy, and 2 rainy days in March. The rains are usually light. March as well as January, February, April, and December is considered the most comfortable time to visit Cayo Santa Maria.